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So do environmental toxins like pesticides, heavy metals, and air pollutants

Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response

The Journal of Clinical Investigation, 123 (1), 92100

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Lau IP, Chen H, Wang J, Ong HC, Leung KC, Ho HP, et al